Part 1 – Do Statins Raise the Risk for Diabetes? by Gregory A. Nichols, PhD

Statins and Risk of Incident Diabetes: A Collaborative Meta-analysis of Randomised Statin Trials

Sattar N, Preiss D, Murray HM, et al

Lancet. 2010;375:735-742. Epub 2010 Feb 16.

Study Summary

Using data from 13 clinical trials with 91,140 participants, the investigators conducted a meta-analysis to determine whether a relationship exists between statin use and the development of diabetes. Six of the trials had previously published data for incident diabetes. The other 7 studies had not analyzed or published data on incident diabetes.

For each trial in the meta-analysis, odds ratios and 95% confidence intervals were calculated on the basis of the number of patients who did not have diabetes at baseline and the number who developed incident diabetes. An overall odds ratio was then calculated with a random-effects model meta-analysis. Meta-regression analysis was also used to investigate potential differences (heterogeneity) between trials. Specifically, baseline age, body mass index (BMI), and percentage of change in low-density lipoprotein (LDL) cholesterol were tested.

Of the 91,140 participants without diabetes, 4278 developed incident diabetes over a mean study follow-up of about 4 years. The rate of diabetes in individual trials varied substantially. Of the 13 trials, 2 independently showed positive associations between statin therapy and incident diabetes. In the combined data, 174 more cases of incident diabetes occurred in the groups assigned to statin treatment than in the placebo or standard-care groups, representing a 9% increase in the likelihood of development of diabetes during follow-up. The investigators estimated that this amounted to 1 additional case of diabetes per 255 patients treated with statins over 4 years. The results were nearly identical when the analyses were restricted to placebo-controlled trials. Heterogeneity between trials was low. Although the association between statin therapy and risk for incident diabetes was stronger in trials with older participants, baseline BMI and percent change in LDL cholesterol did not seem to be important factors.

Young Naturopathic Wellness Center

The Young Naturopathic Wellness Center was founded to provide patients with appropriate diagnoses and effective, individualized treatment and education to help them achieve wellness. Dr Renee Young can treat cholesterol without using statins, especially if you are at risk of Diabetes.

To achieve your own wellness, call 408.761.6781 today to schedule your appointment. For more information about the Young Naturopathic Center for Wellness, visit http://www.drreneeyoung.com/ and http://www.youngwellnesscenter.com

Watch our video to learn more about Diabetes, statins

http://www.youtube.com/watch?v=ueaLn8vrZ_g

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